Ordidge: Melbourne Brain Centre Imaging Unit
The Melbourne Brain Centre Imaging Unit at Parkville has been established as a consequence of the procurement of major funding via the Federal government Education Investment Fund (EIF) and the Victorian State government Victoria’s Science Agenda (VSA) Investment Fund, together with funds provided by the University of Melbourne and FINMH. The Melbourne Brain Centre Imaging Unit is led by Professor Roger Ordidge, Chair of Imaging Sciences.
Although the Melbourne Brain Centre Imaging Unit is based around imaging machines, the consortium places emphasis on being engaged with the scientific community to enable appropriate usage of the technologies. In combination, these advanced imaging technologies will lead to advances in the diagnosis and hopefully, the eventual treatment of a wide range of neurological disorder. This necessitates close collaboration between University of Melbourne scientists and engineers and those in associated institutes, public teaching hospitals, and national and international centres of research excellence.
Human Brain Imaging on a 7 Tesla Siemens MRI Research Scanner
The 7 Tesla MRI scanner is jointly funded by the University of Melbourne, the Florey Institute of Neuroscience and Mental Health and the National Imaging Facility. Working in the Melbourne Brain Centre Imaging Unit, we will perform cutting edge, high field studies of the brain to investigate a wide range of human diseases and disorders. Sodium imaging and imaging of MR visible nuclei other than protons will also be performed together with methodological improvements in functional, structural, diffusion-weighted and perfusion-weighted MRI. New studies will also use the capabilities of the PET/CT scanner in combination with MRI to study brain function and biochemistry in greater detail.
The Melbourne Brain Centre Imaging Unit currently houses a state-of-the-art Siemens combined Positron Emission Tomography/ Computerised X-ray Tomography (PET/CT) system for scanning the human brain and body. Radio-pharmaceuticals can be scanned in order to study tissue function and metabolism and novel biomarkers are being used to study brain disorders such as Alzheimer's disease. The system can perform time of flight measurements, has an extended field of view PET with 128 slice CT.
Dr Jon Cleary, McKenzie Post-Doctoral Research Fellow
Shawna Farquharson, Chief Radiographer - MRI
A/Prof Leigh Johnston, Melbourne School of Engineering
Dr Sonal Josan, Visiting Scientist
Dr Scott Kolbe, Research Fellow
Vikki Marshall, Administration
Dr Brad Moffat, Senior Research Fellow
Claire Mulcahy, Senior Radiographer - MRI
Dr Amanda Ng, Research Fellow
Fiona Rogers, Administration
Dr Rishma Vidyasagar, Research Fellow
Rob Williams, Chief Research Technologist – PET/CT
Yasmin Blunck, PhD student (Melbourne School of Engineering)
Peter Yoo, PhD student (School of Biomedical Sciences)
David Wright, PhD student (School of Biomedical Sciences)
James Korte, PhD student (Melbourne School of Engineering)
Rosa Shishegar, PhD student (Melbourne School of Engineering)
Warda Syeda, PhD student (Melbourne School of Engineering)
The Melbourne Brain Centre Imaging Unit has close collaborations with researchers from many local, national and international institutions, including The University of Melbourne, CSIRO, Monash University, The Florey Institute of Neuroscience and Mental Health, Murdoch Children’s Research Institute, Royal Melbourne Hospital, St Vincent’s Hospital, The Austin Hospital, Karolinska Institutet and the Victorian University of Technology.
The Melbourne Brain Centre Imaging Unit currently holds facility and project funding from many organisations and funding bodies, including the National Imaging Facility (NIF), Victorian Biomedical Imaging Capability (VBIC), National Health and Medical Research Council (NHMRC), The University of Melbourne, The Florey Institute of Neuroscience and Mental Health, The Austin Hospital, Department of Defence (USA), and pharmaceutical industry partners.
A full list of MBCIU publications from 2011 - 15 can be found under "Download Research Publications (PDF)"
- Thayyil S, Cleary JO, Sebire NJ, Scott RJ, Chong K, Gunny R, Owens CM, Olsen OE, Offiah AC, Parks HG, Chitty LS, Price AN, Yousry TA, Robertson NJ, Lythgoe MF, Taylor AM. Post-mortem examination of human fetuses: a comparison of whole-body high-field MRI at 9.4 T with conventional MRI and invasive autopsy. Lancet 2009; 374(9688): 467-75.
- Cleary JO*, Modat M*, Norris FC, Price AN, Jayakody SA, Martinez-Barbera JP, Greene ND, Hawkes DJ, Ordidge RJ, Scambler PJ, Ourselin S, Lythgoe MF. Magnetic resonance virtual histology for embryos: 3D atlases for automated high-throughput phenotyping. NeuroImage 2011; 54(2): p769-78. *Joint first authorship
- Cleary JO*, Norris FC*, Siow BM*, Wells JA, De Castro SCP, Ordidge RJ, Greene NDE, Scambler PJ, Alexander DC, Lythgoe MF. Diffusion microscopic magnetic resonance imaging of the mouse embryo: protocol and practical implementation in the splotch mouse model.
Magnetic Resonance in Medicine 2015; 73(2): p731-9. *Joint first authorship
- Layton KJ, Tahayori B, Mareels IMY, Farrell PM, Johnston LA. Rabi resonance in spin systems: theory and experiment. Journal of Magnetic Resonance 2014; 242:136-42,.
- Davey C, Grayden DB, Egan GF, Johnston LA. Filtering induces correlation in fMRI resting state data. NeuroImage 2013; 64:728-40.
- Schmierer K, Parkes HG, So PW, An SF, Brandner S, Ordidge RJ, Yousry TA, Miller DH. High field (9.4 Tesla) magnetic resonance imaging of cortical grey matter lesions in multiple sclerosis. Brain 2010; 133(3): 858-867.
- Tabrizi SJ, Langbehn DR, Leavitt BR, Roos RAC, Durr A, Craufurd D, Kennard C, Hicks SL, Fox NC, Scahill RI, Borowsky B, Tobin AJ, Rosas HD, Johnson H, Reilmann R, Landwehrmeyer B, Stout JC et al. Quantitative assessment of biological and clinical manifestations of Huntingtons disease before and after diagnosis the TRACK-HD study. Lancet Neurology 2009; 8(9):791-801.
- Shmueli K, Thomas DL , Ordidge RJ. Design, construction and evaluation of an anthropomorphic head phantom with realistic susceptibility artifacts. J Mag Reson. Imag 2007, 26(1): 202-7.
- Priest AN, De Vita E, Thomas DL, Ordidge RJ. EPI distortion correction from a simultaneously acquired distortion map using TRAIL. J Magn Reson Imaging 2006; 23(4):597-603.
- Carmichael DW, Thomas DL, De Vita E, Fernandez Seara MA, China N, Cooper M, Sunderland C, Randell C, Turner R, Ordidge RJ. Improving whole brain structural MRI at 4.7 Tesla using 4 irregularly shaped receiver coils. Neuroimage 2006; 32(3): 1176-84.
- Thomas DL, De Vita E, Deichmann R, Turner R, Ordidge RJ. 3D MDEFT imaging of the human brain at 4.7T with reduced sensitivity to radiofrequency inhomogeneity. Magnetic Resonance in Medicine 2005; 53(6): 1452-8.
- Kinchesh P, Ordidge RJ. Spin-echo MRS in humans at high field: LASER localization using using FOCI pulses. Journal of Magnetic Resonance 2005; 175(1): 30-43.