Transcriptional control of the MYC oncogene
The transcription factor and cell growth regulator MYC is upregulated in 70% of all human cancers. As therapeutically targeting MYC itself has proved unfeasible, we need to find new ways to indirectly target MYC in cancer. Most MYC-driven cancer is due to upregulation of expression, but the networks controlling MYC transcription in malignancy are largely unknown. The single stranded DNA binding protein FBP is essential for transcription of the MYC oncogene, and dysregulation of FBP is linked with a wide variety of cancers, eg. kidney, breast, liver, lung, bladder, prostate, gastrointestinal and brain. This research aims to use a combination of in vivo genetic models (Drosophila and mouse) and human cancer models to unravel the mechanisms for regulation of MYC expression by FBP.
Dr Leonie Quinn