Cancer stem cell models

Project Details

The discovery of cancer stem cells (CSCs) emphasized the importance of interactions between stem cells and their microenvironment. Years of research in Drosophila have documented the capacity of the supporting cellular environment or "niche" in maintenance and behaviour of stem cell (SC) populations. In the context of cancer, the microenvironment normally prevents tumour formation by controlling stem cell renewal and differentiation. This project aims to use sophisticated Drosophila stem cell models to identify the signals from the niche required to control levels of the MYC oncogene in the germline stem cells, which is important to prevent the formation of germline tumours (below).

Researchers

Dr Leonie Quinn

Research Group

Quinn laboratory: Developmental cancer models



Faculty Research Themes

Cancer

School Research Themes

Cancer, Molecular Mechanisms of Disease



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Anatomy and Neuroscience