Cancer stem cell models
The discovery of cancer stem cells (CSCs) emphasized the importance of interactions between stem cells and their microenvironment. Years of research in Drosophila have documented the capacity of the supporting cellular environment or "niche" in maintenance and behaviour of stem cell (SC) populations. In the context of cancer, the microenvironment normally prevents tumour formation by controlling stem cell renewal and differentiation. This project aims to use sophisticated Drosophila stem cell models to identify the signals from the niche required to control levels of the MYC oncogene in the germline stem cells, which is important to prevent the formation of germline tumours (below).
Dr Leonie Quinn