Live cell imaging of neural crest cell migration along the developing gut
Our laboratory has devised methods for imaging the migration of neural crest cells along explants of embryonic mouse gut by using mice in which enteric neural crest cells express fluorescent proteins.
In this project you will use time-lapse imaging and a transgenic mouse in which neural crest cells within the embryonic gut express a novel fluorescent protein to identify (a) the rules that govern the migratory behaviour of neural crest cells within developing gut, and (b) the mechanisms by which endothelin-3 and Rho GTPases influence enteric neural crest cell migratory behaviour.
Professor Heather Young
Faculty Research Themes
School Research Themes
For further information about this research, please contact the research group leader.