Young laboratory: Development of the enteric nervous system
Within the wall of the gut, there is an extensive nervous system, the enteric nervous system, which plays an essential role in the control of gut motility.
During development, enteric neurons arise from neural crest cells that emigrate from the caudal hindbrain and migrate into and along the developing gut. Enteric neural crest cells are thought to migrate further than any other embryonic cell population.
Our research is focused on the mechanisms controlling the development of the enteric nervous system and the potential of cell therapy for treating diseases of the enteric nervous system.
Dr Lincon Stamp, Senior Research Officer
Dr Marlene Hao, NHMRC CJ Martin Fellow
Ms Annette Bergner, Senior Research Assistant
Mr Horace Chan, Research Assistant
Ms Jan Morgan, Technical Officer
Professor Hideki Enomoto, Kobe University, Japan
Professor John Furness, University of Melbourne
Professor Joel Bornstein, University of Melbourne
Associate Professor Alan Lomax, Queen’s University, Canada
Dr Jaime Foong, University of Melbourne
NHMRC Project Grant APP1079234: "Cell therapies for enteric neuropathies - the essential next step". HM Young, LA Stamp and JC Bornstein.
ARC Discovery Project DP150103709: "Neural migration: Which cells advance and which stay behind?" HM Young.
NHMRC Project Grant APP1063822: "Differentiation and fate in developing sympathetic ganglia". CR Anderson, HM Young.
2014-16 (extended until 31.12.17), $340K,
- Foogng JPP, Hirst CS, Hao MM, McKeown SJ, Boesmans W, Young HM*, Bornstein JC* and Vanden Berghe P.* Changes in nicotinic neurotransmission during enteric nervous system development. J Neurosci 2015; 35: 7106-7115 *equal senior authors
- Young HM, Stamp LA, Hofstra RMW. Hirschsprung Disease and activation of hedgehog signaling via GLI1-3 mutations. Gastroenterology 2015; 149: 1672-5.
- Chan WH, Stamp LA, Hirst CS, McKeown SJ, Anderson CR, Young HM. Development of the autonomic nervous system. Reviews in Cell Biology and Molecular Medicine 2016; 2: 23-65.
- Burns AJ, Goldstein AM, Newgreen DF, Stamp L, Schafer KH, Metzger M, Hotta R, Young HM, Andrews PW, Thapar N, Belkind-Gerson J, Bondurand N, Bornstein JC, Chan WY, Cheah K, Gershon MD, Heuckertoh RO, Hofstra RMW, Just L, Kapur RP, King SK, McCann C, Nagy N, Ngan E, Obermayr F, Pachnis V, Pasricha PJ, Sham MH, Tam P, Vanden Berghe P. White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies. Dev Biol 2016; 417: 229-251.
- Young HM, McKeown SJ. Hirschsprung disease - laying down a suitable path. Nat Rev Gastro Hepatol 2016; 13: 7-8.
- Parish IA, Stamp LA, Lorenzo A, Fowler S, Sontani Y, Miosge LA, Howard DR, Goodnow CC, Young HM, Furness JB. A novel mutation in the nucleoporin Nup35 causes murine degenerative colonic smooth muscle myopathy. Am J Path 2016; 186: 2254-61.
- Stamp LA, Gwynne RM, Foong JPP, Lomax AE, Hao MM, Kaplan D, Reid CA, Petrou S, Allen AM, Bornstein JC, Young HM. Optogenetic demonstration of functional innervation of postnatal mouse colon by neurons derived from transplanted neural cells. Gastroenterology 2017; 152: 1407-1418.
- McKeown SJ, Mohsenipour M, Bergner AJ, Young HM, Stamp LA. Exposure to GDNF enhances the ability of enteric neural progenitors to generate an enteric nervous system. Stem Cell Reports 2017; 8: 476-488
- Migration of melanoma cells in the neural crest environment
- Proliferation of enteric neuron precursors
- Potential of cell therapy to treat Hirschsprung’s disease
- Live cell imaging of neural crest cell migration along the developing gut
Faculty Research Themes
School Research Themes
For further information about this research, please contact Professor Heather Young