Characterisation of immune evasion mechanisms in novel and emerging viruses
The recent emergence/re-emergence of viruses such as Nipah/Hendra, rabies/Australian lyssavirus, Ebola and SARS highlights the dangers of spill-over to humans of pathogens that cause disease in animals. Immune evasion is a critical factor in determining the potential for an interspecies viral invasion.
We have investigated the functions of proteins from diverse viruses, including established, emerging and novel potentially zoonotic viruses from humans, cattle, bats and rodents. Using techniques including live-cell imaging, mass-spectroscopy and next-generation sequencing, we identified novel interactions that subvert host immunity. Current projects are examining the molecular basis of these effects with a focus on understanding the biology of novel and emerging viruses.
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