Gametocytogenesis - the sexy side of malaria

Project Details

The falciparum malaria parasite undergoes remarkable transformations that allow asexual stage multiplication in a human host and sexual reproduction in a mosquito vector. Inhibition of this process would ablate disease transmission. Despite the importance of this parasite stage, little is known of the mechanisms controlling its shape, form, and function, or of the mechanisms by which gametocytes adhere within the vasculature and then re-enter the circulation. The Tilley laboratory is generating transgenic gametocytes expressing fluorescently labelled proteins to gain an understanding of the host cell modifications required for these processes.

super-resolution optical microscopy image of a Plasmodium falciparum gametocyte

Super-resolution optical microscopy image of a Plasmodium falciparum gametocyte

Research Group

Tilley laboratory: Measuring and modelling malaria parasites to develop new antimalarials

Faculty Research Themes

Infection and Immunology

School Research Themes

Infection & Immunity, Molecular Mechanisms of Disease

Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Biochemistry and Molecular Biology