Several genes that are implicated in neurodegenerative disease have been suggested to be important in the biology of RNA binding and stress granule formation.
In a new project in collaboration with Archa Fox and Charlie Bond at University of Western Australia, we are investigating the process by which stress granules form and how mutations that cause amyotrophic lateral sclerosis impact on the formation of these granules. Questions include how do these structures form? How do they form scaffolds to hold the RNA in the granules? What is the link between stress granule formation and problems with protein misfolding and aggregation?
Faculty Research Themes
School Research Themes
For further information about this research, please contact the research group leader.