Detecting and mapping different protein conformations in live cells
Many cellular functions are driven by changes in the conformation of proteins; some conformational changes act as molecular switches for regulating normal cellular activities, while others are non-normal and result in detrimental outcomes to the cell. Our laboratory studies how proteins change conformation in live cells and how different conformations engage with the surrounding cellular machinery.
A key platform is the development of new fluorescence-based approaches for visualization of distinct conformations of specific disease associated proteins, such as those involved in cancer and neurodegenerative disease.
Figure 1: Huntingtin aggregation in the cellular environment.
Are monomers, oligomers or aggregates toxic?
How do they influence the cellular machinery?
What is their temporal and spatial localization?
Faculty Research Themes
School Research Themes
For further information about this research, please contact the research group leader.