Detecting and Mapping Different Protein Conformations in Live Cells

Project Details

Many cellular functions are driven by changes in the conformation of proteins; some conformational changes act as molecular switches for regulating normal cellular activities, while others are non-normal and result in detrimental outcomes to the cell. Our laboratory studies how proteins change conformation in live cells and how different conformations engage with the surrounding cellular machinery.

A key platform is the development of new fluorescence-based approaches for visualization of distinct conformations of specific disease associated proteins, such as those involved in cancer and neurodegenerative disease.

Huntingtin aggregation in the cellular environment

Figure 1: Huntingtin aggregation in the cellular environment.
Are monomers, oligomers or aggregates toxic?
How do they influence the cellular machinery?
What is their temporal and spatial localization?

Research Group

Hatters Laboratory: Protein Misfolding and Proteostasis in Neurodegenerative Diseases



Faculty Research Themes

Neuroscience

School Research Themes

Neuroscience, Molecular Mechanisms of Disease, Cellular Imaging & Structural Biology



Key Contact

For further information about this research, please contact the research group leader.

Department / Centre

Biochemistry and Molecular Biology