Gleeson Laboratory: Membrane Trafficking and Protein Sorting in Health and Disease and Development of New Therapeutics

Overview

'Our aim is to understand the molecular basis of membrane and protein sorting in the secretory and endocytic pathways in a variety of physiological processes using cultured cells and differentiated primary cells, and to exploit this knowledge for the design of new therapeutics.' Professor Paul Gleeson

Our laboratory uses a range of state-of-the-art techniques in cell biology, molecular biology and molecular immunology to investigate:

  • Membrane trafficking
    • Membrane trafficking underpins many physiological processes, including secretion, receptor signalling, endocytosis, antigen presentation, and neural networking. Many diseases arise from defects in membrane trafficking, including Alzheimer’s disease.
    • Our laboratory has developed strategies for studying trafficking in primary cells and whole organisms.
    • There are three main projects underway in this area
  • Molecular immunology and autoimmunity

diagram showing membrane trafficking pathways

Figure 1: Membrane trafficking pathways

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Staff

Fiona Houghton, MSc Senior research assistant
Dr Prajakta Gosavi, Post Doc
Dr Jade Louber, Post Doc
Dr Wei Hong Toh, Post Doc
Kelly Zulkefli, PhD Student
Anson Tan, PhD Student
Christian Makhoul, Honours Student
Chenkun Zhao, Honours Student

Recent past lab members

Ismail Mahmoud, PhD Student
Sarah Overall, PhD Student
Dr Cheryl Chia, Post Doc
Dr Dorothee Bourges, Post Doc
Dr Jet Phey Lim, Post Doc
Dr Robert Lieu, Post-doc
Dr Sofia Nystrom Post-doc
Regina Duffied, Research Assistant

photo of Gleeson Lab Group early 2016

Collaborators

Professor Ian van Driel, Department of Biochemistry and Molecular Biology, The University of Melbourne
Prof Danny Hatters, Department of Biochemistry and Molecular Biology, The University of Melbourne
Dr Justine Mintern, Department of Biochemistry and Molecular Biology, The University of Melbourne
Professor Malcolm McConville, Department of Biochemistry and Molecular Biology, The University of Melbourne
Professor Steven Dower, CSL, Bio21

Funding

NHMRC Project Grant: 'Membrane trafficking of BACE1 and amyloid precursor protein in primary neurons and production of Ab amyloid peptides'.
ARC Discovery Project: 'The function of the ribbon structure of the Golgi apparatus in vertebrates'.
ARC Linkage Project: 'Intracellular trafficking and function of a recycling receptor that prolongs the serum half-life of novel therapeutic proteins'.

Research Publications

Click here for the results of a PubMed search of Paul's publications.

Click here for the results of a Google Scholar analysis of Paul's publications.