Laureate Professor Peter Doherty

Other Doherty pages

1. Honours, awards, fellowships and medals
2. Honorary Degrees
3. Consultant activities
4. Publications: Original articles
5. Solicited reviews, book chapters and commentary

Academic Degrees

BVSc 1962 University of Queensland, Australia (Veterinary Science)
MVSc 1966 University of Queensland, Australia (Veterinary Science)
PhD 1970 University of Edinburgh, Scotland (Pathology)

Bio

Professor Peter Doherty shared the Nobel Prize in Physiology or Medicine in 1996 with Swiss colleague Rolf Zinkernagel, for their discovery of how the immune system recognises virus-infected cells. He was Australian of the Year in 1997, and has since been commuting between St Jude Children's Research Hospital in Memphis and the Department of Microbiology and Immunology at the University of Melbourne. His research is mainly in the area of defence against viruses. He regularly devotes time to delivering public lectures, writing articles for newspapers and magazines and participating in radio discussions.

Peter Doherty graduated from the University of Queensland in Veterinary Science and became a veterinary officer. Moving to Scotland, he received his PhD from the University of Edinburgh Medical School. He is the first person with a veterinary qualification to win a Nobel Prize.

Peter is also the author of several books, including "The Beginners Guide to Winning the Nobel Prize", "A Light History of Hot Air", "Sentinel Chickens:What Birds Tell Us About our Health And Our World", "Pandemics: What Everyone Needs to Know",  "The Knowledge Wars" and "Incidential Tourist".

Professional Appointments

1/1/72 to 31/5/75
Postdoctoral Fellow (6 months), Research Fellow, Department of Microbiology, The John Curtin School of Medical Research, Australian National University, Canberra

1/6/75 to 30/12/82
Associate Professor/Professor, The Wistar Institute, Philadelphia, Pennsylvania

1/1/82 to 31/3/88
Professor and Head, Department of Experimental Pathology, The John Curtin School of Medical Research, Australian National University, Canberra

1/4/88 to present
Member and Chairman (till 2001), Dept. of Immunology (Michael F. Tamer Chair of Biomedical Research), St. Jude Children's Research Hospital, Memphis, Tennessee (Emeritus from January 2017, but still holding the Tamer Chair)

1/7/02 to present
Laureate Professor, Dept of Microbiology & Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne

Professional Society Memberships

Australian Society for Immunology (F) {1993}
American Association of Pathologists {1988}
Neuroimmunology Society {2004}
American Association of Veterinary Immunologists (F) {1988}
Scandinavian Society of Immunology (F) {1998}
Australian Society for Medical Research (F) {1998}
American College of Veterinary Pathologists (F) {1988}
Royal College of Veterinary Surgeons (F) {1967}
(F) = Honorary Fellow, or equivalent

Research Interests

Cell-mediated immunity
T cell recognition and repertoire
Immunological tolerance
Viral immunology
Immunopathology
Immune memory

Active Grant Support

NHMRC Program Grant, No 1071916, Project Title: Limiting The Impact of Influenza
01/01/2015 – 31/12/2019 – $13,617,890 over five years. CI List: CIA - Prof Stephen Turner, CIB - Prof David Jackson, CIC - Prof Lorena Brown, CID - Prof Weisan Chen, CIE - A/Prof Katherine Kedzierska, CIF - A/Prof Nicole La Gruta & CIG Prof Peter Doherty.

NHMRC Program Grant: 122524 (2017 - 2020) Project Title: Generation of protective immunity against severe influenza disease in Indigenous Australians.  Total $1,630,970.00. AI – Prof Peter Doherty.

Published Interview

1. Suzanne Vogle, Discoveries Down Under.
   Journal of NIH Research (Re: Zinkernagel RM, Doherty PC.
   Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system Nature [Lond] 248:701-702, 1974) J NIH Res 3:68-72, 1991.

Reprint of Key Paper

1. Zinkernagel RM, Doherty PC.
   Pillars Article: Immunological Surveillance against Altered Self Component by Sensitised T Lymphocytic Choriomeningitis.
   Nature, 1974, 251: 547-548.
   J Immunol 2004 Sep 1;173 (5) :2899-900.

Unpublished Theses

1. Studies in the experimental pathology of louping-ill encephalitis. Edinburgh, 1970.
2. The epizootiology of bovine leptospirosis. Queensland, 1966.

Books

"The Beginner's Guide to Winning the Nobel Prize", Miegunyah Press, Melbourne University Publishing, September, 2005; Columbia University Press, NY, May 2006.

"A Light History of Hot Air", Miegunyah Press, Melbourne University Publishing, September, 2007.

"Sentinel Chickens: What Birds Tell Us About Our Health And Our World", Miegunyah Press, Melbourne University Publishing, July, 2012.

"Pandemics: What Everyone Needs to Know", The Experiment Publishing, NY, September, 2013.

"The Knowledge Wars" Miegunyah Press, Melbourne University Publishing, August 2015.

"Incedential Tourist" Miegunyah Press, Melbourne University Publishing, September 2018.

Editorial

Parasite Immunology 1979-1982
Journal of Neuroimmunology 1980-
Journal of Immunology , Section Editor 1980-1982; 1990-1996
Infection and Immunity 1981-1984
Journal of Veterinary Immunology and Immunopathology 1983-1986
Journal of Virology 1984-1986; 1996-1999
Microbial Pathogenesis 1985
Archives of Virology 1986-198
Virology 1990-
Viral Immunology 1994-
Immunity 2000-
Editor for volume 4, No. 2 of Seminars in Immunology, 1992
Editor for volume 6, No. 4 of Current Opinion in Immunology, 1994

Teaching

AAI seminar course in Advanced Immunology, Colorado Springs, 1991-1995

Students

The following have successfully completed Ph.D. theses while working with me:

1. R. M. Zinkernagel, March 1975 (ANU); Professor of Experimental Biology, University of Zurich, Switzerland.
2. R. B. Effros, June 1978 (Wistar Institute); Professor, University of California at Los Angeles.
3. J. R. Bennink, August 1978 (Wistar Institute); Chief, Viral Immunology Laboratory, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
4. N. Greenspan, MD/PhD, July 1981 (Wistar Institute); Associate Professor, Department of Pathology, Case Western Reserve University, Cleveland, OH.
5. D. Schwartz, MD/PhD, December 1982 (Wistar Institute); Johns Hopkins University, Baltimore, MD.
6. N. Bowern, May 1986 (ANU); Commonwealth Department of Health, Canberra, Australia.
7. J. Dixon, September 1987 (ANU); Postdoctoral Fellow, Suny, Stonybrook, New York
8. Z. Tabi, September 1988 (ANU); Research Associate, University of Queensland, Australia.
9. M. F. Uren, November 1988 (ANU); CSIRO Senior Research Scientist, Division of Tropical Sciences, Brisbane, Australia.
10. X. Y. Mo, University of Tennessee, Postdoctoral Fellow, University of Massachusetts.

Recent Publications (2010-current)

List of Publications prior to 2010

1. Rutigliano JA, Morris MY, Yue W, Keating R, Webby RJ, Thomas PG, Doherty PC. Protective memory responses are modulated by priming events prior to challenge. J Virol 2010 Jan; 84(2): 1047-56.
2. Juelich T, Sutcliffe E, Denton A, He Y, Doherty PC, Parish C, Turner SJ, Tremethick D, Rao S. Interplay between Chromatin Remodeling and Epigenetic Changes during Lineage-Specific Commitment to Granzyme B Expression. J Immunol 2010 Dec 1; 183(11): 7063-7072.
3. Thomas PG, Brown SA, Morris MY, Yue W, So J, Reynolds C, Webby RJ, Doherty PC. Physiological Numbers of CD4+ T Cells Generate Weak Recall Responses Following Influenza Virus Challenge. J Immunol 2010 Feb 15; 184(4): 1721-7.
4. Theodossis A, Guillonneau C, Welland A, Ely LK, Clements CS, Williamson NA, Webb AI, Wilce JA, Mulder RJ, Dunstone MA, Doherty PC, McCluskey J, Purcell AW, Turner SJ, Rossjohn J. Constraints within major histocompatibility complex class I restricted peptides: Presentation and consequences for T-cell recognition. Proc Natl Acad Sci U S A 2010 March 23; 107(12): 5534-5539.
5. La Gruta NL, Rothwell WT, Cukalac T, Swan NG, Valkenburg SA, Kedzierska K, Thomas PG, Doherty PC, Turner SJ. Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion. J Clin Invest 2010 Jun 1; 120(6): 1885-94.
6. Cukalac T, Valkenburg SA, La Gruta NL, Turner SJ, Doherty PC, Kedzierska K. Multiplexed combinatorial tetramer staining in a mouse model of virus infection. J Immunol Methods 2010; 360: 157-161.
7. Gras S, Kedzierski L, Valkenburg SA, Laurie K, Liu YC, Denholm JT, Richards MJ, Rimmelzwaan GF, Kelso A, Doherty PC, Turner SJ, Rossjohn J, Kedzierska K. Cross-reactive CD8+ T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses. Proc Natl Acad Sci U S A 2010 July 12; 107(28): 12599-12604.
8. Valkenburg SA, Day EB, Swan NG, Croom HA, Carbone FR, Doherty PC, Turner SJ, Kedzierska K. Fixing an irrelevant TCRalpha chain reveals the importance of TCRbeta diversity for optimal TCRalphabeta pairing and function of virus-specific CD8(+) T cells. Eur J Immunol 2010 Sep; 40(9): 2470-81.
9. Valkenburg SA, Gras S, Guillonneau C, La Gruta NL, Thomas PG, Purcell AW, Rossjohn J, Doherty PC, Turner SJ, Kedzierska K. Protective Efficacy of Cross-Reactive CD8 T Cells Recognising Mutant Viral Epitopes Depends on Peptide-MHC-I Structural Interactions and T Cell Activation Threshold. PLoS Pathog 2010 Aug 12; 6(8). pii: e1001039.
10. Moffat JM, Handel A, Doherty PC, Turner SJ, Thomas PG, La Gruta NL. Influenza Epitope-Specific CD8+ T Cell Avidity, but Not Cytokine Polyfunctionality, Can Be Determined by TCR{beta} Clonotype. J Immunol 2010 Dec 1; 185(11): 6850-6856.
11. Dash P, McClaren JL, Oguin TH 3rd, Rothwell W, Todd B, Morris MY, Becksfort J, Reynolds C, Brown SA, Doherty PC, Thomas PG. Paired analysis of TCRα and TCRβ chains at the single-cell level in mice. J Clin Invest 2011 Jan 4; 121(1): 288-295.
12. Croom HA, Denton AE, Valkenburg SA, Swan NG, Olson MR, Turner SJ, Doherty PC, Kedzierska K. Memory precursor phenotype of CD8(+) T cells reflects early antigenic experience rather than memory numbers in a model of localized acute influenza infection. Eur J Immunol 2011 Mar; 41(3): 682-93.
13. Day EB, Charlton KL, La Gruta NL, Doherty PC, Turner SJ. Effect of MHC Class I Diversification on Influenza Epitope-Specific CD8+ T Cell Precursor Frequency and Subsequent Effector Function. J Immunol 2011 Jun 1; 186(11): 6319-28.
14. Venturi V, Davenport MP, Swan NG, Doherty PC, Kedzierska K. Consequences of suboptimal priming are apparent for low-avidity T-cell responses. Immunol Cell Biol 2012 Feb; 90(2): 216-23.
15. Wu C, Zanker D, Valkenburg S, Tan B, Kedzierska K, Zou QM, Doherty PC, Chen W. Systematic identification of immunodominant CD8+ T-cell responses to influenza A virus in HLA-A2 individuals. Proc Natl Acad Sci U S A 2011 May 31; 108(22): 9178-9183.
16. Day EB, Guillonneau C, Gras S, La Gruta NL, Vignali DA, Doherty PC, Purcell AW, Rossjohn J, Turner SJ. Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses. Proc Natl Acad Sci U S A 2011 May 2; 108(23): 9536-9541.
17. Denton AE, Russ BE, Doherty PC, Rao S, Turner SJ. Differentiation-dependent functional and epigenetic landscapes for cytokine genes in virus-specific CD8+ T cells. Proc Natl Acad Sci U S A 2011 Sept 13; 108(37): 15306-15311.
18. Denton AE, Wesselingh R, Gras S, Guillonneau C, Olson MR, Mintern JD, Zeng W, Jackson DC, Rossjohn J, Hodgkin PD, Doherty PC, Turner SJ. Affinity Thresholds for Naive CD8+ CTL Activation by Peptides and Engineered Influenza A Viruses. J Immunol 2011 Dec 1; 187(11): 5733-44.
19. Valkenburg SA, Venturi V, Dang TH, Bird NL, Doherty PC, Turner SJ, Davenport MP, Kedzierska K. Early Priming Minimizes the Age-Related Immune Compromise of CD8 T Cell Diversity and Function. PLoS Pathog 2012 Feb; 8(2): e1002544. doi: 10.1371/journal.ppat.1002544. Epub 2012 Feb 23. Erratum in: PLoS Pathog. 2012 Mar;8(3). doi: 10.1371/annotation/e142f9de-7f30-4759-bda1-a651e86d5ba6.
20. Kedzierska K, Curtis JM, Valkenburg SA, Hatton LA, Kiu H, Doherty PC, Kedzierski L. Induction of Protective CD4(+) T Cell-Mediated Immunity by a Leishmania Peptide Delivered in Recombinant Influenza Viruses. PLoS One 2012; 7(3):e33161.
21. Wang GC, Dash P, McCullers JA, Doherty PC, Thomas PG. T Cell Receptor αβ Diversity Inversely Correlates with Pathogen-Specific Antibody Levels in Human Cytomegalovirus Infection. Sci Transl Med 2012 Apr 4; 4(128):128ra42.
22. Kedzierska K, Valkenburg SA, Doherty PC, Davenport MP, Venturi V. Use it or lose it: establishment and persistence of T cell memory. Front Immunol 2012 Nov 3: 357.
23. Thomas PG, Handel A, Doherty PC, La Gruta NL. Ecological analysis of antigen-specific CTL repertoires defines the relationship between naive and immune T-cell populations. Proc Natl Acad Sci U S A 2013 Jan 29; 110(5): 1839-44.
24. Fouchier RA, García-Sastre A, Kawaoka Y, Barclay WS, Bouvier NM, Brown IH, Capua I, Chen H, Compans RW, Couch RB, Cox NJ, Doherty PC, Donis RO, Feldmann H, Guan Y, Katz JM, Kiselev OI, Klenk HD, Kobinger G, Liu J, Liu X, Lowen A, Mettenleiter TC, Osterhaus AD, Palese P, Peiris JS, Perez DR, Richt JA, Schultz-Cherry S, Steel J, Subbarao K, Swayne DE, Takimoto T, Tashiro M, Taubenberger JK, Thomas PG, Tripp RA, Tumpey TM, Webby RJ, Webster RG. Transmission studies resume for avian flu. Science 2013 Feb 1;339(6119):520-1.
25. Sanders CJ, Vogel P, McClaren JL, Bajracharya R, Doherty PC, Thomas PG. Compromised respiratory function in lethal influenza infection is characterized by the depletion of type I alveolar epithelial cells beyond threshold levels. Am J Physiol Lung Cell Mol Physiol 2013 Apr; 304(7):L481-8.
26. Valkenburg SA, Gras S, Guillonneau C, Hatton LA, Bird NA, Twist KA, Halim H, Jackson DC, Purcell AW, Turner SJ, Doherty PC, Rossjohn J, Kedzierska K. Preemptive priming readily overcomes structure-based mechanisms of virus escape. Proc Natl Acad Sci U S A 2013 Apr 2; 110(14): 5570-5.
27. Lupfer C, Thomas PG, Anand PK, Vogel P, Milasta S, Martinez J, Huang G, Green M, Kundu M, Chi H, Xavier RJ, Green DR, Lamkanfi M, Dinarello CA, Doherty PC, Kanneganti TD. Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat Immunol 2013 May; 14(5): 480-8.
28. Askovich PS, Sanders CJ, Rosenberger CM, Diercks AH, Dash P, Navarro G, Vogel P, Doherty PC, Thomas PG, Aderem A.  Differential host response, rather than early viral replication efficiency, correlates with pathogenicity caused by influenza viruses. PLoS One. Sep 20;8(9):e74863, 2013.
29. Keating R, Hertz T, Wehenkel M, Harris TL, Edwards BA, McClaren JL, Brown SA, Surman S, Wilson ZS, Bradley P, Hurwitz J, Chi H, Doherty PC, Thomas PG, McGargill MA. The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus. Nat Immunol. Dec;14(12):1266-76, 2013.
30. Valkenburg SA, Quiñones-Parra S, Gras S, Komadina N, McVernon J, Wang Z, Halim H, Iannello P, Cole C, Laurie K, Kelso A, Rossjohn J, Doherty PC, Turner SJ, Kedzierska K.  Acute emergence and reversion of influenza A virus quasispecies within CD8(+) T cell antigenic peptides. Nat Commun. Oct 30;4:2663, 2013.
31. Rosenberger CM, Podyminogin RL, Askovich PS, Navarro G, Kaiser SM, Sanders CJ, McClaren JL, Tam VC, Dash P, Noonan JG, Jones BG, Surman SL, Peschon JJ, Diercks AH, Hurwitz JL, Doherty PC, Thomas PG, Aderem A. Characterization of innate responses to influenza virus infection in a novel lung type I epithelial cell model. J Gen Virol. Feb;95(Pt2):350-62, 2014.
32. Rutigliano JA, Sharma S, Morris MY, Oguin TH 3rd, McClaren JL, Doherty PC, Thomas PG.  Highly pathologic influenza A virus infection is associated with augmented expression of PD-1 by functionally-compromised virus-specific CD8+ T cells. J Virol. Feb;88(3):1636-51, 2014.
33. Wang Z, Zhang A, Wan Y, Liu X, Qiu C, Xi X, Ren Y, Wang J, Dong Y, Bao M, Li L, Zhou M, Yuan S, Sun J, Zhu Z, Chen L, Li Q, Zhang Z, Zhang X, Lu S, Doherty PC, Kedzierska K, Xu J. Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection. Proc Natl Acad Sci U S A. Jan 14;111(2):769-74, 2014.
34. Quiñones-Parra S, Grant E, Loh L, Nguyen TH, Campbell KA, Tong SY, Miller A, Doherty PC, Vijaykrishna D, Rossjohn J, Gras S, Kedzierska K. Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities. Proc Natl Acad Sci U S A. Jan 21;111(3):1049-54, 2014.
35. Cukalac T, Chadderton J, Handel A, Doherty PC, Turner SJ, Thomas PG, La Gruta NL. Reproducible selection of high avidity CD8+ T-cell clones following secondary acute virus infection.  Proc Natl Acad Sci U S A. Jan 28;111(4):1485-90, 2014.
36. Harland KL, Day EB, Apte SH, Russ BE, Doherty PC, Turner SJ, Kelso A. Epigenetic plasticity of Cd8a locus during CD8(+) T-cell development and effector differentiation and reprogramming. Nat Commun. Mar 28;5:3547, 2014.
37. Cukalac T, Chadderton J, Zeng W, Cullen JG, Kan WT, Doherty PC, Jackson DC, Turner SJ, La Gruta NL.  The Influenza Virus-Specific CTL Immunodominance Hierarchy in Mice Is Determined by the Relative Frequency of High-Avidity T Cells. J Immunol. May 1;192(9):4061-8, 2014.
38. Olson MR, Seah SG, Edenborough K, Doherty PC, Lew AM, Turner SJ. CD154(+) CD4(+) T-cell dependence for effective memory influenza virus-specific CD8(+) T-cell responses. Immunol Cell Biol. Aug;92(7):605-11, 2014.
39. McMichael AJ, Leeder SR, Armstrong BK, Basten A, Doherty PC, Douglas RM, Green AC, Nossal GJ, Shearman DJ, Stanley FJ, Vimpani GV, Wodak AD.  Open letter to the Hon Tony Abbott MP.  Med J Aust. Sep 1;201(5):252, 2014.
40. Olson MR, Seah SG, Cullen J, Greyer M, Edenborough K, Doherty PC, Bedoui S, Lew AM, Turner SJ. Helping Themselves: optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells.  J Immunol. 1;193(11):5420-33, 2014.
41. Clemens EB, Doherty PC, La Gruta NL, Turner SJ. Fixed expression of single influenza virus-specific TCR chains demonstrates the capacity for TCR α- and β-Chain diversity in the face of peptide-MHC class I specificity. J Immunol. Feb 1;194(3):898-910, 2015.
42. Duan S, Meliopoulos VA, McClaren JL, Guo XZ, Sanders CJ, Smallwood HS, Webby RJ, Schultz-Cherry SL, Doherty PC, Thomas PG. Diverse heterologous primary infections radically alter immunodominance hierarchies and clinical outcomes following H7N9 influenza challenge in mice. PLoS Pathog. Feb 10;11(2):e1004642, 2015.
43. Wang Z, Wan Y, Qiu C, Quiñones-Parra S, Zhu Z, Loh L, Tian D, Ren Y, Hu Y, Zhang X, Thomas PG, Inouye M, Doherty PC, Kedzierska K, Xu J.  Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8⁺ T cells. Nat Commun. May 13;6:6833, 2015.
44. Tscharke DC, Croft NP, Doherty PC, La Gruta NL. Sizing up the key determinants of the CD8(+) T cell response. Nat Rev Immunol.  Nov;15(11):705-16, 2015.
45. Chua BY, Wong CY, Mifsud EJ, Edenborough KM, Sekiya T, Tan AC, Mercuri F, Rockman S, Chen W, Turner SJ, Doherty PC, Kelso A, Brown LE, Jackson DC.  Inactivated Influenza Vaccine That Provides Rapid, Innate-Immune-System-Mediated Protection and Subsequent Long-Term Adaptive Immunity.  MBio. Oct 27;6(6):e01024-15, 2015.
46. Doherty P.  The Red and white: ancient history. Nat Rev Immunol. Feb;16(2):77, 2016.
47. Quinn KM, Zaloumis SG, Cukalac T, Kan WT, Sng XY, Mirams M, Watson KA, McCaw JM, Doherty PC, Thomas PG, Handel A, La Gruta NL. Heightened self-reactivity associated with selective survival, but not expansion, of naïve virus-specific CD8+ T cells in aged mice. Proc Natl Acad Sci U S A. Feb 2;113(5):1333-8, 2016.
48. Valkenburg SA, Josephs TM, Clemens EB, Grant EJ, Nguyen TH, Wang GC, Price DA, Miller A, Tong SY, Thomas PG, Doherty PC, Rossjohn J, Gras S, Kedzierska K. Molecular basis for universal HLA-A*0201-restricted CD8+ T-cell immunity against influenza viruses. Proc Natl Acad Sci U S A. Apr 19;113(16):4440-5, 2016.
49. Olson MR, Chua BY, Good-Jacobson KL, Doherty PC, Jackson DC, Turner SJ. Competition within the virus-specific CD4 T cell pool limits the T follicular helper response after influenza infection.  Immunol Cell Biol. Sep;94(8):729-40, 2016.
50. Loh L, Wang Z, Sant S, Koutsakos M, Jegaskanda S, Corbett AJ, Liu L, Fairlie DP, Crowe J, Rossjohn J, Xu J, Doherty PC, McCluskey J, Kedzierska K. Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation. Proc Natl Acad Sci U S A. Sep 6;113(36):10133-8, 2016.
51. Quinn KM, Kan WT, Watson KA, Liddicoat BJ, Swan NG, McQuilten H, Denton AE, Li J, Chen W, Brown LE, Jackson DC, Reading PC, Doherty PC, Kedzierska K, Kedzierski L, Turner SJ, La Gruta NL. Extrinsically derived TNF is primarily responsible for limiting antiviral CD8+ T cell response magnitude. PLoS One. Sep 8;12(9):e0184732, 2017.
52. Wang Z, Zhu L, Nguyen THO, Wan Y, Sant S, Quiñones-Parra SM, Crawford JC, Eltahla AA, Rizzetto S, Bull RA, Qiu C, Koutsakos M, Clemens EB, Loh L, Chen T, Liu L, Cao P, Ren Y, Kedzierski L, Kotsimbos T, McCaw JM, La Gruta NL, Turner SJ, Cheng AC, Luciani F, Zhang X, Doherty PC, Thomas PG, Xu J, Kedzierska K. Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease.  Nat Commun. Feb 26;9(1):824, 2018.
53. Quinn KM, Fox A, Harland KL, Russ BE, Li J, Nguyen THO, Loh L, Olshanksy M, Naeem H, Tsyganov K, Wiede F, Webster R, Blyth C, Sng XYX, Tiganis T, Powell D, Doherty PC, Turner SJ, Kedzierska K, La Gruta NL. Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells. Cell Rep. Jun 19;23(12):3512-3524, 2018.
54. Krammer F, Smith GJD, Fouchier RAM, Peiris M, Kedzierska K, Doherty PC, Palese P, Shaw ML, Treanor J, Webster RG, García-Sastre A. Influenza. Nat Rev Dis Primers. Jun 28;4(1):3, 2018.
55. Keating R, Morris MY, Yue W, Reynolds CE, Harris TL, Brown SA, Doherty PC, Thomas PG, McGargill MA. Potential killers exposed: tracking endogenous influenza-specific CD8+ T cells. Immunol Cell Biol. Nov;96(10):1104-1119, 2018.
56. Cullen JG, McQuilten HA, Quinn KM, Olshansky M, Russ BE, Morey A, Wei S, Prier JE, La Gruta NL, Doherty PC, Turner SJ. CD4+ T help promotes influenza virus-specific CD8+ T cell memory by limiting metabolic dysfunction. Proc Natl Acad Sci U S A. 2019 Feb 20.